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KMID : 0614720110540010088
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Journal of Korean Medical Association
2011 Volume.54 No. 1 p.88 ~ p.91
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Pharmacological treatment for reflux esophagitis
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Jung Hwoon-Yong
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Abstract
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Proton pump inhibitors (PPIs) can ameliorate reflux symptoms and heal esophageal injury by rapid inhibition of acid secretion. PPIs are used as an initial treatment as well as for main-tenance purposes. Eight weeks are necessary for complete healing of esophageal injury. After initial therapy, symptomatic recurrence rates are as high as 85% within one year. Therefore, to maintain a good quality of life, many patients need half or usual dose of a PPI for maintenance. There are three kinds of maintenance therapy including continuous, intermittent, and on-demand therapy. PPIs are very safe to use. Adverse events including headache, skin rashes, diarrhea, and weakness have a very low prevalence. Longstanding use of a PPI, however, may be asso-ciated with several medical problems such as community-acquired infection and osteoporosis because of a chronic intragastric hypochlorhydric state. PPIs are definitely superior to H2-receptor antagonists and other medications in terms of their treatment potency and safety.
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KEYWORD
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Proton pump inhibitors, Step-down therapy, Maintenance therapy, Adverse effects
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